There was no evidence of publication bias for the continuous outcomes (p = 0.995; S3 Fig). Maternal misperception and concern on childhood obesity play a bigger role in identifying, preventing and seeking for the treatment of childhood obesity. POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. No, Is the Subject Area "Metaanalysis" applicable to this article? Maternal Employment and Childhood Obesity: A Search for Mechanisms in Time Use Data. There was no evidence of publication bias in the analyses of overweight or obese children (p > 0.05; S3 Fig). There was substantial heterogeneity between studies. US-based indices of area-level deprivation: results from HealthCare for Communities. Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: results from a Swedish total population and discordant sibling study. Authors who responded to our correspondence and provided the data requested were Dr Aline Andres, Professor Patrick Catalano, Dr Romy Gaillard, Professor Dana Dabelea, Dr Ai Kubo, Professor David Taylor-Robinson, Dr Sophie Wickham, Professor Christine Olson, and Dr Stephen Weng. HL has participated as an advisory board member, consultant and speaker for Nestlé Nutrition Institute and Nestlé Finland. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). This systematic review and meta-analysis aimed to determine the dose–response association between maternal pre-pregnancy BMI and offspring obesity. If the adjusted ORs and CIs were not available, the respective unadjusted parameters were derived from the data. Influence of maternal obesity on the long-term health of offspring. As adipocytes accumulate fatty acids and become enlarged (ie, adipocyte hypertrophy), mechanisms respond to restrict their size, including upregulating immune cells, which lead to increased inflammatory cytokines in both maternal and fetal circulation.4 In a sheep experiment, fetuses of obese ewes had increased circulation of free fatty acids coupled with upregulation of inflammatory genes in their placentas compared with controls.41 To further understand causal relationships, interventions to counter inflammation through dietary modification among obese pregnant women has been suggested.2. Understanding the relationship between mothers' health and childhood obesity would give health professions new educational tools to prevent childhood obesity and obesity in general as The 22 studies [20,33,34,36,38,40–44,46,52,56–61,70–73] with data available to be pooled for meta-analysis included 31,328 cases of overweight or obesity among 181,800 children aged 1 to 16 years. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. The systematic review was registered on the PROSPERO database (reference CRD42016035599). To assess a potential nonlinear trajectory, we estimated the odds of failure relative to categorical time. Because of the smaller numbers of twins, we could not conduct analysis among them with 9 parental obesity groups. Female mice were fed control or obesogenic diets . Sep 16, 2021, 04:30AM IST Source: ANI. Research Spotlights: September 2021. Adjusted odds ratios (aORs) and 95% confidence intervals were estimated by using generalized linear mixed models accounting for maternal covariates (ie, age, race, education, insurance, marital status, parity, and pregnancy smoking). Questions included information regarding both parents’ height and weight, maternal weight before pregnancy, and total GWG. There was no evidence of publication bias in the analyses of children with obesity (p = 0.53; S3 Fig). Some of these health issue and health behaviors are maternal BMI, and infant nursing methods. Fourteen studies reported data for child overweight (85th to 95th percentile); 10 of these could be pooled for meta-analysis [33,34,36,38,40–44,46]. Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years. Article Google Scholar 34. Writing – original draft, Please cite this work as: Centre for Maternal and Child Enquiries (CMACE). When both parents had BMI of ≥35, an additional association with the problem-solving domain emerged. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. between maternal employment, childhood obesity, diet, and physical activity in China, a particularly interesting topic for three reasons: First, research outside the Western world is so limited thatit is impossible to assess the ext entto which the positive relation between maternal employment and childhood obesity can be The majority of additional ORs reported for maternal overweight and child obesity were statistically significant, ranging from 1.04 to 3.36. Childhood obesity has increased dramatically in both developed and developing countries [].It has been suggested that prenatal, perinatal and postnatal environmental factors impact childhood obesity [].Some studies have found that intrauterine exposure to maternal gestational diabetes mellitus (GDM) places offspring at increased risk of long-term adverse outcomes, including obesity [3-12]. This attention is essential for future public health and clinical research, policy, and practice, given the inequalities associated with obesity. Unable to load your collection due to an error, Unable to load your delegates due to an error, The circles, squares and triangles represent odds ratios (ORs) (A and C) or regression coefficients (B and D) (95% confidence intervals) obtained from multilevel binary logistic or linear regression models that reflect the risk of overweight/obesity or differences in early, mid, and late childhood BMI standard deviation score (SDS) in the different maternal pre-pregnancy BMI or gestational weight gain groups, as compared to the reference group (20.0–22.5 kg/m. Thus, we sought to examine to what extent the association between in utero exposure to maternal overweight/obesity and childhood overweight . The first part of this book covers the impact of nutrition on the immune system, the role of gut microbiota in the immune status, as well as the prevention and management of food allergies in children. Sensitivity analyses for linear and nonlinear meta-analyses did not show any 1 study to be substantially influencing the overall direction of association, effect size, statistical significance, or heterogeneity (S14–S17 Tables). Writing – original draft, Inclusion criteria were peer-reviewed studies reporting both the exposure variable (maternal pre- or early-pregnancy BMI) and the outcome variable (offspring BMI or z-score) among children aged 1–18 years. Dose–response meta-analyses were conducted to investigate the association between maternal and child BMI. Int J Obes. This research adds to the substantial evidence base that the causes of obesity involve a complex interplay between in utero and life course exposures, which may unequally affect those with a predisposition to obesity. From this percentage, near the half (13.6 percentage points) correspond to obesity prevalence. Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children, SARS-CoV-2 Among Infants <90 Days of Age Admitted for Serious Bacterial Infection Evaluation, Newborn Pulse Oximetry for Infants Born Out-of-Hospital, Follow American Academy of Pediatrics on Instagram, Visit American Academy of Pediatrics on Facebook, Follow American Academy of Pediatrics on Twitter, Follow American Academy of Pediatrics on Youtube, Racism and Its Effects on Pediatric Health, www.pediatrics.org/cgi/content/full/135/5/e1198, www.pediatrics.org/cgi/content/full/127/1/e202, www.pediatrics.org/cgi/content/full/133/5/e1128, www.pediatrics.org/cgi/content/full/131/5/e1468, www.pediatrics.org/cgi/content/full/118/4/e1178. FOIA Institute of Health & Society, Newcastle University, Newcastle upon Tyne, United Kingdom, Roles Of these studies, 56 were prospective, 21 reported national-level data, and the majority (n = 63) were published since 2010. Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A, Bergström A, Bird PK, Brescianini S, Ní Chaoimh C, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Costet N, Criswell R, Crozier S, Eggesbø M, Fantini MP, Farchi S, Forastiere F, van Gelder MMHJ, Georgiu V, Godfrey KM, Gori D, Hanke W, Heude B, Hryhorczuk D, Iñiguez C, Inskip H, Karvonen AM, Kenny LC, Kull I, Lawlor DA, Lehmann I, Magnus P, Manios Y, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Rusconi F, Santos AC, Sørensen TIA, Standl M, Stoltenberg C, Sunyer J, Thiering E, Thijs C, Torrent M, Vrijkotte TGM, Wright J, Zvinchuk O, Gaillard R, Jaddoe VWV. Additional life course exposures include socio-economic status, food production and marketing, food insecurity, and obesogenic environments, which promote unhealthy lifestyles to which some individuals are genetically more susceptible [99,101–103]. Twelve studies reported maternal obesity, and 5 reported GWG. Investigation, Examining unique substance-related risk profiles for neglectful . Found insideThis comprehensive volume covers all aspects of nutrition in different scenarios of maternal diabetes, including the Type 1 or Type 2 diabetic mother, gestational diabetes, and postpartum diabetes. However, the specificity of the associations for maternal and paternal obesity suggests that associations were not wholly attributed to a shared family environment.25 We used a validated screening tool demonstrated to identify early developmental delays,28,43 but did not have systematic developmental assessments of all children. There is a global obesity crisis, particularly among women and disadvantaged populations. This book summarizes the effects of overweight/obesity in the childbearing years that can be effectively communicated to patients by their providers in a busy practice setting, and provides concise and understandable summaries of the ... Categorical outcomes were child obesity (≥95th percentile, primary outcome), overweight/obesity (≥85th percentile), and overweight (85th to 95th percentile). Specifically, at 2 years (n = 6850), the study found no association with psychomotor development (encompassing fine and gross motor) but observed a relation with delayed mental development.5 We had previously found that maternal obesity was associated with delayed developmental milestones, such as a longer time to sitting alone and crawling39; however, no associations were found with later milestones involving standing or walking alone.39 The lack of longer-term association is consistent with our current investigations of gross motor development. PLoS One. Rationale: Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms.. Nevertheless, our findings provide suggestive evidence for a differential role of paternal obesity on the personal-social domain (attributes close to those evidenced in ASD). Heterogeneity was present in all analyses (I2 92.3%–99.9%; S18 Table). Maternal obesity pre-pregnancy has also been linked to interim effects on the mother and the This paper explores mechanisms for that correlation. Prevention and treatment information (HHS). In line with our findings, one large prospective study conducted in The Netherlands (2001-2005) reported that maternal obesity was more likely to be associated with childhood obesity (OR = 5.02, 95% CI, 2.97-8.45) when compared to maternal normal weight (22). Disappointingly, we identified limited data from low- and middle-income countries. When two obese parents are worse than one! This systematic review has strengths and limitations. This study aimed to assess parental perceptions, concerns about weight, feeding practices using the Child Feeding Questionnaire (CFQ), and its association with body mass index (BMI) and maternal education in elementary school children. Associations similar to maternal BMI may suggest residual confounding from socioeconomic or shared postnatal influences.25 On the other hand, dissimilar associations can support true intrauterine programming specific to maternal BMI. Associations (aOR [95% CI]) Between Maternal Obesity and ASQ Fails in the Primary Cohort of Upstate KIDS. The Upstate KIDS Study recruited 5034 women ∼4 months after a delivery in New York State (excluding New York City) between 2008 and 2010. GWG was modeled with the adequate weight gain group as reference. Association of maternal caffeine intake during pregnancy with low birth weight, childhood overweight, and obesity: a meta-analysis of cohort studies. The red dotted line represents the linear trend. Autism and Other Neurodevelopmental Disorders gathers and organizes the most recent information in this important and rapidly expanding field into a clinically useful volume that will enable clinicians, patients, and families to understand ... Feeding practices in pregnancy and infancy: relationship with the development of overweight and obesity in childhood. Bringing together experts from a variety of specialties to examine the issues and challenges of obesity, this book discusses how obesity affects fertility, reproduction and pregnancy. Epub 2021 Jul 5. Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity. Found inside – Page iThis volume will explore the epidemiology and the basic mechanisms of each of these prenatal phenomena, in an attempt to explain the role of the prenatal environment in promoting postnatal weight gain. Maternal misperception and concern on childhood obesity play a bigger role in identifying, preventing and seeking for the treatment of childhood obesity. Linearity was not rejected for either measure when analysed separately (S8 Table). For obese, the midpoint was selected as being 35 kg/m2, reflecting that the majority of pregnant women with obesity have class I (BMI 30–34.9 kg/m2) or class II (BMI 35–39.9 kg/m2) obesity [10]. Publication bias was tested for using Egger’s test [16]. A 5-stage search strategy was implemented to limit the effect of publication bias, as database searches alone are insufficiently rigorous [8]. Yes A total of 79 studies reporting data from 59 cohorts are reported in this review (Fig 1). A study by Salsberry and Reagan (2005) suggested that maternal prepregnancy obesity influences early childhood obesity, which is . Supplementary searches included hand-searching reference lists, performing citation searching, and contacting authors. Funding acquisition, eCollection 2021. Investigation, Writing – original draft, Roles The book, a collaborative effort between the World Bank and UNICEF, is targeted at all those involved in developing and implementing nutrition interventions in Egypt and beyond. Children (WIC) population, rates of maternal overweight and obesity and childhood overweight were similar to the national trends (11, 12). Our results cannot be directly compared with previous studies because we evaluated different domains of development by using the ASQ, a validated screening rather than diagnostic tool. Childhood health consequences of maternal obesity during pregnancy: a narrative review. A large linkage study in Sweden observed that maternal obesity was associated with risk of offspring autism but not after analyses were restricted to siblings, suggesting associations may not be causal and that familial risk factors that are incompletely controlled for may still play a role.19 Alternatively, some studies have found that childhood obesity itself may be related to poorer cognitive development.40, The potential mechanisms explaining how maternal obesity may affect offspring development, largely drawn from animal evidence, has been previously reviewed.3,4 Inflammation remains a leading explanation. Using the random effects dose–response model ( grey line ) this research found... From 1 to 3 years a linear prediction model was built, and mechanistic pathways to impaired health offspring! Normal/Underweight groups 72.9 %, 72.9 %, and the continuous variable plotted. 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Obesity: epidemiology and health behaviors are maternal BMI to neurodevelopment in.... Examining infertility treatment and early childhood obesity across different maternal body mass index child... Pediatric Collections on COVID-19 and Racism and its association with reduced odds of problem-solving domain.. Reporting continuous maternal BMI Biggest Indicator of risk for childhood obesity.. design Four focus.! Vieira R, Akhter Z, Bailey H, Slack E, Ngongalah L, et al such. Bmi ≥35 were likely to additionally fail the problem-solving domain Fails until both paternal and maternal report to BMI... On birth outcomes in Suriname height and weight, childhood overweight and gestational diabetes mellitus GDM. Are temporarily unavailable [ 108 ] effects dose–response model ( grey line ) obesity and excessive weight... Citation: Heslehurst N, Vieira R, Santos s, Duijts L, Felix JF Third... 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